| Opponent | W | L | T | First | Last |
| Adrian | 5 | 2 | 0 | 1995 | 2006 |
| Albany State | 1 | 0 | 0 | 1969 | 1969 |
| Albion | 2 | 2 | 0 | 1902 | 1991 |
| Allegheny | 0 | 1 | 0 | 2001 | 2001 |
| Anderson | 13 | 33 | 0 | 1897 | 2006 |
| Arkansas State | 1 | 0 | 0 | 1960 | 1960 |
| Armour Institute | 0 | 1 | 0 | 1921 | 1921 |
| Ashland | 0 | 1 | 0 | 1979 | 1979 |
| Augustana | 2 | 2 | 0 | 1983 | 1983 |
| Aurora | 2 | 9 | 0 | 1987 | 1995 |
| Ball State | 35 | 42 | 2 | 1926 | 1972 |
| Beloit | 0 | 2 | 0 | 1898 | 1898 |
| Benedictine | 3 | 0 | 0 | 2004 | 2006 |
| Berry | 1 | 2 | 0 | 1973 | 1974 |
| Bethany | 1 | 1 | 0 | 1915 | 1993 |
| Blackburn | 3 | 3 | 0 | 2003 | 2005 |
| Bloomfield | 0 | 1 | 0 | 1992 | 1992 |
| Bradley Polytechnic | 1 | 0 | 0 | 1924 | 1924 |
| Bunker Hill | 0 | 2 | 0 | 1944 | 1944 |
| Butler | 64 | 62 | 1 | 1880 | 2003 |
| Calvin | 10 | 3 | 0 | 1984 | 1991 |
| Camp Atterbury | 2 | 1 | 0 | 1944 | 1945 |
| Camp Taylor | 1 | 0 | 0 | 1920 | 1920 |
| Canterbury | 2 | 3 | 0 | 1947 | 1950 |
| Carleton | 1 | 0 | 0 | 1982 | 1982 |
| Carthage | 0 | 1 | 0 | 2005 | 2005 |
| Central Methodist | 1 | 0 | 0 | 1992 | 1992 |
| Centre | 25 | 7 | 0 | 1996 | 2006 |
| Charleston Normal | 2 | 0 | 0 | 1925 | 1925 |
| Chicago | 7 | 8 | 0 | 1938 | 2005 |
| Chicago Circle | 0 | 1 | 0 | 1975 | 1975 |
| Cincinnati | 0 | 3 | 0 | 1903 | 1932 |
| Clark Atlanta | 2 | 0 | 0 | 1999 | 1999 |
| Columbus College | 0 | 3 | 0 | 1974 | 1980 |
| Concordia (Ill.) | 1 | 1 | 0 | 2006 | 2006 |
| Cumberland (Ky.) | 0 | 2 | 0 | 2003 | 2003 |
| Danville Normal | 0 | 1 | 0 | 1930 | 1930 |
| Earlham | 52 | 5 | 1 | 1908 | 1997 |
| Eastern Illinois Normal | 1 | 1 | 0 | 1909 | 1910 |
| Edinboro | 1 | 0 | 0 | 1989 | 1989 |
| Eli Lilly | 1 | 0 | 0 | 1907 | 1907 |
| Elmhurst | 3 | 0 | 0 | 1993 | 2005 |
| Emory | 3 | 9 | 0 | 1992 | 2006 |
| Evansville | 25 | 19 | 0 | 1926 | 1977 |
| Fairmont St | 3 | 0 | 0 | 1989 | 1989 |
| Flagler | 0 | 2 | 0 | 1990 | 1991 |
| Florida A&M | 1 | 4 | 0 | 1966 | 1969 |
| Fontbonne | 0 | 1 | 0 | 1997 | 1997 |
| Fort Benjamin Harrison | 0 | 1 | 0 | 1946 | 1946 |
| Franklin | 84 | 22 | 1 | 1907 | 2006 |
| Freeman | 0 | 1 | 0 | 1944 | 1944 |
| Georgetown (KY) | 1 | 1 | 1 | 1903 | 1908 |
| Georgia Field | 0 | 1 | 0 | 1944 | 1944 |
| Georgia Southwestern | 0 | 3 | 0 | 1974 | 1974 |
| Georgia Tech | 0 | 3 | 0 | 1968 | 1973 |
| Goshen | 3 | 2 | 0 | 1921 | 2001 |
| Great Lakes | 0 | 1 | 0 | 1944 | 1944 |
| Greencastle Professional | 1 | 1 | 0 | 1902 | 1902 |
| Greenville | 3 | 1 | 0 | 1982 | 2003 |
| Grinnell | 2 | 1 | 0 | 1995 | 1996 |
| Hanover | 38 | 28 | 0 | 1892 | 2006 |
| Hawaii | 0 | 2 | 0 | 1915 | 1916 |
| Hendrix | 0 | 2 | 0 | 1999 | 2003 |
| Hillsdale | 1 | 1 | 0 | 1990 | 1992 |
| Hope | 6 | 8 | 0 | 1963 | 2005 |
| Illinois College | 0 | 1 | 0 | 1998 | 1998 |
| Illinois, U. of | 1 | 13 | 0 | 1888 | 1982 |
| Illinois Wesleyan | 4 | 9 | 0 | 1987 | 1998 |
| Indiana | 26 | 111 | 2 | 1884 | 2005 |
| Indiana Central | 20 | 25 | 0 | 1926 | 1978 |
| Indiana Law | 2 | 0 | 0 | 1902 | 1909 |
| Indiana State | 47 | 59 | 2 | 1895 | 2001 |
| Indiana Tech | 2 | 0 | 0 | 1978 | 1978 |
| Indianapolis League | 0 | 1 | 0 | 1902 | 1902 |
| Indianapolis Training School | 1 | 0 | 0 | 1898 | 1898 |
| Indianapolis University | 3 | 0 | 0 | 1898 | 1899 |
| ISU-Evansville | 1 | 1 | 0 | 1979 | 1979 |
| IUPU-Ft. Wayne | 9 | 1 | 0 | 1978 | 1995 |
| IUPUI | 13 | 7 | 0 | 1980 | 1995 |
| IU-Kokomo | 2 | 0 | 0 | 1994 | 1994 |
| IU-Northwest | 2 | 0 | 0 | 2000 | 2000 |
| IU-Southeast | 3 | 3 | 0 | 1981 | 1983 |
| John Carroll | 0 | 1 | 0 | 1989 | 1989 |
| Kalamazoo | 3 | 1 | 0 | 1903 | 1989 |
| Kentucky | 2 | 1 | 0 | 1903 | 1908 |
| Kentucky State | 2 | 8 | 0 | 1904 | 1920 |
| Kenyon | 1 | 0 | 0 | 1894 | 1894 |
| Knox | 1 | 1 | 0 | 1904 | 1905 |
| Ladoga | 1 | 1 | 0 | 1907 | 1907 |
| LaGrange | 1 | 2 | 0 | 2002 | 2006 |
| Lake Forest | 4 | 0 | 0 | 1904 | 1907 |
| Louisville | 8 | 8 | 0 | 1910 | 1959 |
| LSU | 0 | 2 | 0 | 1961 | 1961 |
| Manchester | 15 | 12 | 0 | 1988 | 2006 |
| Marian | 14 | 15 | 0 | 1967 | 2006 |
| Marietta | 0 | 3 | 0 | 1977 | 1998 |
| Maryville (Mo.) | 6 | 0 | 0 | 1994 | 1996 |
| Memphis State | 0 | 2 | 0 | 1955 | 1956 |
| Methodist (N.C.) | 0 | 2 | 0 | 1998 | 1998 |
| Miami (Oh.) | 9 | 4 | 0 | 1898 | 1970 |
| Miami-Middletown | 8 | 0 | 0 | 1995 | 1996 |
| Michigan | 1 | 1 | 0 | 1895 | 1903 |
| Michigan Aggies | 0 | 2 | 0 | 1911 | 1921 |
| Middle Tennessee State | 1 | 0 | 0 | 1966 | 1966 |
| Milligan (Tenn.) | 2 | 0 | 0 | 1995 | 1995 |
| Millikin | 8 | 1 | 0 | 1905 | 1993 |
| Millsaps | 2 | 7 | 0 | 2000 | 2006 |
| Milwaukee Sch. of Engineering | 2 | 1 | 0 | 1998 | 2001 |
| Mississippi college | 1 | 1 | 0 | 2001 | 2001 |
| Moore's Hill | 1 | 0 | 0 | 1910 | 1910 |
| Moravian | 0 | 1 | 0 | 1992 | 1992 |
| Mt. Mercy | 3 | 0 | 0 | 1988 | 1988 |
| Mount St. Joseph | 5 | 6 | 0 | 1996 | 2006 |
| Muskingum | 1 | 1 | 0 | 1989 | 1989 |
| Nebraska | 1 | 0 | 0 | 1899 | 1899 |
| Nichols State | 0 | 2 | 0 | 1961 | 1961 |
| North Central | 3 | 0 | 0 | 1974 | 1999 |
| North Florida | 0 | 2 | 0 | 1988 | 1988 |
| North Park | 5 | 1 | 0 | 1989 | 2006 |
| Northeastern Illinois | 7 | 8 | 0 | 1972 | 1983 |
| Northwestern | 0 | 2 | 0 | 1904 | 1950 |
| Notre Dame | 3 | 17 | 0 | 1898 | 1987 |
| Oakland City | 11 | 3 | 0 | 1926 | 1984 |
| Oberlin | 10 | 4 | 0 | 1942 | 1990 |
| Oglethorpe | 26 | 13 | 0 | 1992 | 2006 |
| Ohio Northern | 2 | 2 | 0 | 1992 | 1993 |
| Ohio State | 1 | 3 | 0 | 1897 | 1905 |
| Ohio University | 0 | 2 | 0 | 1931 | 1932 |
| Ohio Wesleyan | 3 | 4 | 0 | 1894 | 2001 |
| Olivet | 4 | 0 | 0 | 1986 | 1991 |
| Otterbein | 0 | 1 | 0 | 1897 | 1897 |
| Piedmont | 1 | 2 | 0 | 1993 | 2006 |
| Point Park | 0 | 1 | 0 | 1998 | 1998 |
| Purdue | 17 | 75 | 0 | 1891 | 1987 |
| Purdue-North Central | 10 | 0 | 0 | 1998 | 2000 |
| Rhodes (Southwestern, Tenn.) | 10 | 4 | 0 | 1955 | 2006 |
| Rockford | 0 | 1 | 0 | 1997 | 1997 |
| Rollins | 0 | 2 | 0 | 1966 | 1966 |
| Rose-Hulman | 101 | 59 | 3 | 1888 | 2006 |
| Sewanee | 26 | 8 | 0 | 1999 | 2006 |
| Simpson | 0 | 1 | 0 | 1992 | 1992 |
| Shorter | 0 | 2 | 0 | 1974 | 1974 |
| Southeastern Louisiana | 0 | 1 | 0 | 1961 | 1961 |
| Southern Maine | 0 | 2 | 0 | 1991 | 1992 |
| Southwestern (Texas) | 2 | 4 | 0 | 2001 | 2005 |
| St. Francis | 2 | 0 | 0 | 1977 | 1977 |
| St. Joseph's | 25 | 23 | 0 | 1938 | 1977 |
| St. Leo | 0 | 1 | 0 | 1985 | 1985 |
| St. Meinrad | 2 | 0 | 0 | 1976 | 1976 |
| St. Norbert | 2 | 0 | 0 | 1997 | 1997 |
| St. Thomas (Minn.) | 0 | 1 | 0 | 1992 | 1992 |
| St. Viator | 1 | 1 | 0 | 1923 | 1925 |
| St. Xavier | 0 | 1 | 0 | 1916 | 1916 |
| Stout Field | 1 | 0 | 0 | 1944 | 1944 |
| Tampa | 0 | 3 | 0 | 1966 | 1985 |
| Taylor | 4 | 4 | 0 | 1989 | 1992 |
| Terre Haute League | 0 | 2 | 0 | 1908 | 1915 |
| Thomas (Ga.) | 1 | 1 | 0 | 1998 | 1998 |
| Thomas More | 3 | 4 | 0 | 1997 | 2005 |
| Toledo | 1 | 2 | 0 | 1956 | 1985 |
| Transylvania | 5 | 2 | 0 | 1920 | 2006 |
| Trinity (Texas) | 2 | 3 | 0 | 1999 | 2004 |
| Trinity Christian | 1 | 0 | 0 | 1991 | 1991 |
| Tri-State | 4 | 2 | 0 | 1979 | 1981 |
| Valdosta State | 1 | 16 | 0 | 1966 | 1998 |
| Valparaiso | 12 | 38 | 0 | 1954 | 1998 |
| Vanderbilt | 0 | 3 | 0 | 1942 | 1973 |
| Wabash | 129 | 125 | 2 | 1866 | 2006 |
| Wakeman | 0 | 1 | 0 | 1945 | 1945 |
| Washington (Mo.) | 26 | 17 | 0 | 1981 | 2006 |
| Webster | 2 | 0 | 0 | 1994 | 1994 |
| West Virginia | 0 | 1 | 0 | 1902 | 1902 |
| West Virginia Wesleyan | 1 | 1 | 0 | 1988 | 1988 |
| Western Kentucky | 0 | 1 | 0 | 1942 | 1942 |
| Wheaton | 5 | 4 | 0 | 1961 | 1975 |
| Widener | 1 | 1 | 0 | 1977 | 1978 |
| Wilkes | 0 | 1 | 0 | 1978 | 1978 |
| Wilmington | 2 | 0 | 0 | 1994 | 1994 |
| Wisconsin | 1 | 2 | 0 | 1898 | 1941 |
| Wisconsin-Platteville | 0 | 1 | 0 | 2004 | 2004 |
| Wittenberg | 7 | 7 | 0 | 1894 | 1999 |
| Wooster | 0 | 2 | 0 | 1977 | 1979 |
| York | 1 | 0 | 0 | 1977 | 1977 |