2000 depauw football schedule/results (6-4, 4-2 scac tri-champions)
| Sept. 2 | *at Rhodes | L, 12-17 |
| Sept. 9 | HANOVER (Community Day) | L, 21-24 |
| Sept. 16 | HOPE | L, 24-30 (OT) |
| Sept. 23 | *TRINITY (Parents' Weekend) | L, 26-30 |
| Oct. 7 | *SEWANEE (Old Gold Day) | W, 19-16 |
| Oct. 14 | at Blackburn | W, 48-7 |
| Oct. 21 | *at Millsaps | W, 14-13 |
| Oct. 28 | *at Centre | W, 30-23 |
| Nov. 4 | *ROSE-HULMAN | W, 10-0 |
| Nov. 11 | at Wabash | W, 27-17 |
| *Southern Collegiate Athletic Conference game | ||