2005 depauw football schedule (7-2, 5-0 SCAC)
Varsity schedule | Junior varsity schedule
| Date | Opponent | Time |
| Sept. 3 | WESLEY, Del. (Community Day) | L, 26-31 |
| Sept. 17 | at Hope | W, 38-12 |
| Sept. 24 | *at Trinity | canceled |
| Oct. 1 | CHICAGO (Family Weekend) | W, 33-9 |
| Oct. 8 | *at Sewanee | W, 34-0 |
| Oct. 15 | *RHODES | W, 7-3 |
| Oct. 22 | *MILLSAPS | W, 51-14 |
| Oct. 29 | *CENTRE (Old Gold) | W, 14-7 |
| Nov. 5 | *at Rose-Hulman | W, 60-21 |
| Nov. 12 | WABASH (Monon Bell) | L, 14-17 |
| *indicates Southern Collegiate Athletic Conference game | ||
| 2005 Junior Varsity Schedule | ||
| Date | Opponent | Time |
| Sept. 26 | at Wabash | W, 28-21 |
| Oct. 3 | at Anderson | W, 22-18 |
| Oct. 24 | WABASH | T, 21-21 |