1999 depauw softball schedule/results (19-18, 3-1 scac)
| Date | Opponent/Tournament | Result |
| March 15 | FRANKLIN | W, 4-0 |
| FRANKLIN | W, 13-5 | |
| March 17 | ANDERSON | L, 2-9 |
| ANDERSON | L, 0-8 | |
| March 21 | #vs. Wilmington (Del.) | W, 6-5 |
| #vs. Hartwick | W, 11-2 | |
| March 22 | #vs. Western Connecticut St. | L, 2-3 |
| #vs. Wisconsin-Superior | W, 9-8 | |
| March 24 | #vs. Kalamazoo | W, 10-2 |
| #vs. Columbia (Mo.) | L, 2-3 | |
| March 25 | #vs. Tufts | L, 2-5 |
| #vs. Chicago | L, 0-12 | |
| March 26 | #vs. Allegheny | L, 0-8 |
| #vs. Coe | L, 0-1 (8 inn.) | |
| March 30 | THOMAS MORE | W, 13-0 |
| THOMAS MORE | W, 16-2 | |
| April 1 | at St. Mary-of-the-Woods | L, 3-4 |
| at St. Mary-of-the-Woods | L, 2-11 | |
| April 6 | at Hanover | L, 6-7 (10 inn.) |
| at Hanover | L, 3-4 | |
| April 9 | vs. Centre at Rhodes | W, 19-0 |
| April 10 | vs. Sewanee (1) | W, 5-2 |
| April 10 | vs. Trinity at Rhodes | L, 3-9 |
| April 11 | at Rhodes | W, 6-1 |
| April 20 | Marian | L, 0-6 |
| MARIAN | W, 6-1 | |
| April 22 | %vs. Rhodes | L, 3-4 |
| %vs. Centre | W, 14-0 | |
| April 23 | %vs. Sewanee | W, 4-1 |
| April 23 | #vs. Rhodes | W, 4-3 (8 inn.) |
| April 24 | #at Trinity | L, 0-3 |
| April 29 | WITTENBERG | W, 2-0 |
| WITTENBERG | W, 3-1 | |
| May 1 | MANCHESTER | W, 4-1 |
| MANCHESTER | W, 7-3 | |
| May 5 | at Illinois Wesleyan | L, 2-7 |
| at Illinois Wesleyan | L, 3-5 | |
#Rebel Spring Games; Osceola, Fla. | %SCAC Championship at Trinity University; San Antonio, Texas | |