2005 depauw softball schedule/results (19-18-1, 4-8 SCAC)
| Date | Opponent | Time |
| Feb. 26 | at Maryville (Mo.) | W, 8-4 (8) |
| at Maryville (Mo.) | L, 1-5 | |
| March 6 | at Transylvania | W, 7-3 |
| at Transylvania | L, 4-6 | |
| March 13 | HANOVER | W, 6-3 |
| HANOVER | W, 10-2 | |
| March 16 | ST. MARY-OF-THE-WOODS | L, 2-12 |
| ST. MARY-OF-THE-WOODS | L, 1-8 | |
| March 19 | vs. Hendrix at Rhodes | W, 11-6 |
| vs. Hendrix at Rhodes | T, 4-4 | |
| March 20 | at Rhodes | W, 9-1 |
| at Rhodes | W, 16-1 | |
| March 22 | #vs. Hope | W, 8-7 |
| #vs. Mount Vernon Nazarene | W, 4-2 | |
| March 25 | #vs. Wisconsin-Eau Claire | L, 0-5 |
| March 25 | #vs. Wisconsin-Superior | W, 3-2 (8) |
| March 30 | at Indianapolis | L, 0-8 |
| at Indianapolis | W, 3-1 (9) | |
| March 31 | ANDERSON | W, 3-2 (8) |
| ANDERSON | W, 2-1 | |
| April 2 | *CENTRE | L, 0-2 (8) |
| *CENTRE | L, 1-4 | |
| April 3 | *CENTRE | W, 5-3 |
| *CENTRE | L, 1-3 (9) | |
| April 5 | at Franklin | W, 4-3 |
| at Franklin | W, 10-5 | |
| April 9 | *at Sewanee | W, 2-1 |
| *at Sewanee | L, 0-2 | |
| April 10 | *at Sewanee | W, 6-2 (8) |
| *at Sewanee | L, 5-6 | |
| April 14 | *at Rose-Hulman | L, 4-5 (10) |
| *at Rose-Hulman | L, 4-5 (8) | |
| April 15 | *at Rose-Hulman | W, 7-0 (8) |
| *at Rose-Hulman | L, 5-6 (12) | |
| April 16 | vs. Goshen at Anderson | L, 0-10 |
| vs. Adrian at Anderson | L, 3-5 | |
| April 22 | vs. Trinity (SCAC Championship at Hendrix College) | L, 1-2 |
| April 23 | vs. Millsaps (SCAC Championship at Hendrix) | L, 0-8 |
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*Southern Collegiate Athletic Conference games #Rebel Spring Games at Orlando, Fla.
Cancelled games |
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