2005-06 depauw women's basketball schedule/results (29-2, 14-0 SCAC)
| Date | Opponent/Tournament | Time/Score |
| Nov. 18 | !vs. Illinois Wesleyan at Washington (Mo.) | W, 72-60 |
| Nov. 19 | !at Washington (Mo.) | L, 61-72 |
| Nov. 23 | at Fontbonne | W, 72-53 |
| Nov. 26 | @vs. Hanover at Wilmington (Ohio) | W, 78-47 |
| Nov. 27 | @at Wilmington | W, 88-75 |
| Dec. 2 | *at Hendrix | W, 76-66 |
| Dec. 4 | *at Rhodes | W, 65-64 |
| Dec. 10 | WILLIAM WOODS | W, 94-56 |
| Dec. 17 | WITTENBERG | W, 85-70 |
| Dec. 21 | WEBSTER | W, 84-44 |
| Dec. 28 | #vs. Lewis & Clark | W, 76-63 |
| Dec. 29 | #vs. Viterbo | W, 84-33 |
| Dec. 31 | #vs. William Paterson | W, 87-56 |
| Jan. 7 | *at Rose-Hulman | W, 87-64 |
| Jan. 13 | *CENTRE | W, 85-39 |
| Jan. 15 | *SEWANEE | W, 106-66 |
| Jan. 20 | *at Millsaps | W, 76-47 |
| Jan. 22 | *at Oglethorpe | W, 88-60 |
| Jan. 27 | *SOUTHWESTERN | W, 87-61 |
| Jan. 29 | *TRINITY | W, 60-57 |
| Feb. 3 | *HENDRIX | W, 103-85 |
| Feb. 5 | *RHODES | W, 69-64 |
| Feb. 10 | *at Centre | W, 83-31 |
| Feb. 12 | *at Sewanee | W, 79-51 |
| Feb. 18 | *ROSE-HULMAN | W, 72-61 |
| Feb. 24 | vs. Millsaps (SCAC Quarterfinals; Memphis, Tenn.) | W, 80-61 |
| Feb. 25 | at Rhodes (SCAC Semifinal) | W, 89-73 |
| Feb. 26 | vs. Trinity (SCAC Championship) | W, 67-65 |
| March 4 | MARYVILLE, TENN (NCAA Second Round) | W, 85-58 |
| March 10 | WHEATON (NCAA Round of 16) | W, 69-60 |
| March 11 | HOPE (NCAA quarterfinal) | L, 60-76 |
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*Southern Collegiate Athletic Conference games
!Washington (Mo.) Tipoff
Tournament |
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