2010 NCAA® Division III Softball Championship
 DePauw University Tigers 2010 Greencastle, Indiana Regional Champions |
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| Thursday, May 13 | |||
| Game 1 | #1 Ohio Northern (37-5) vs. #8 Thomas More (22-18) | Ohio Northern, 5-1 | RECAP | BOX SCORE | PHOTOS |
| Game 2 | #4 North Central (31-12) vs. #5 Trine (26-13) | North Central, 8-6 | RECAP | BOX SCORE | PHOTOS |
| Game 3 | #3 Washington.-St. Louis (34-9) vs. #6 Transylvania (34-9) | Transylvania, 4-2 | RECAP | BOX SCORE | PHOTOS |
| Game 4 | #2 DePauw (35-6) vs. #7 Denison (30-15) | DePauw, 5-0 | RECAP | BOX SCORE | PHOTOS |
| Friday, May 14 | |||
| Game 5 | Thomas More vs. Trine | Trine, 5-2 (TMC eliminated) | RECAP | BOX SCORE | PHOTOS |
| Game 6 | Washington vs. Denison | Washington, 5-0 (DU eliminated) | RECAP | BOX SCORE | PHOTOS |
| Game 7 | Ohio Northern vs. North Central | Ohio Northern, 4-3 | RECAP | BOX SCORE | PHOTOS |
| Game 8 | Transylvania vs. DePauw | DePauw, 8-6 (8) | RECAP | BOX SCORE | PHOTOS |
| Saturday, May 15 | |||
| Game 9 | Washington vs. North Central | Washington, 5-0 (NCC eliminated) | RECAP | BOX SCORE | PHOTOS |
| Game 10 | Trine vs. Transylvania | Trine, 4-0 (Transy eliminated) | RECAP | BOX SCORE | PHOTOS |
| Game 11 | Ohio Northern vs. DePauw | DePauw, 6-2 | RECAP | BOX SCORE | PHOTOS 1 2 |
| Game 12 | Washington vs. Trine | Washington, 7-5 (Trine eliminated) | RECAP | BOX SCORE | PHOTOS |
| Sunday, May 16 | |||
| Game 13 | Washington vs. Ohio Northern | Ohio Northern, 7-3 (WU eliminated) | RECAP | BOX SCORE | PHOTOS |
| Game 14 | DePauw vs. Ohio Northern | Ohio Northern, 9-6 | RECAP | BOX SCORE | PHOTOS 1 2 |
| Monday, May 17 | |||
| Game 15 |
Ohio Northern vs. DePauw |
DePauw, 5-4 (DePauw advances to NCAA Finals) | RECAP | BOX SCORE | PHOTOS |