Research by Samuel Rund '08 in Proceedings of the National Academy of Sciences

August 12, 2011

August 12, 2011, Greencastle, Ind. — Samuel S.C. Rund, a 2008 graduate of DePauw University, is lead author of research published in the latest edition (August 9, 2011; vol. 108, no. 32) of Proceedings of the National Academy of Sciences. Rund and four others contribute "Genome-wide profiling of diel and circadian gene expression in the malaria vector Anopheles gambiae."

An abstract of the article notes, "Anopheles gambiae, the primary African vector of malaria parasites, exhibits numerous rhythmic behaviors including flight activity, swarming, mating, host seeking, egg laying, and sugar feeding. However, little work has been performed to elucidate the molecular basis for these daily rhythms. To study how gene expression is regulated globally by diel and circadian mechanisms, we have undertaken a DNA microarray analysis of An. gambiae under light/dark cycle (LD) and constant dark (DD) conditions ... This study highlights the fundamental roles that both the circadian clock and light play in the physiology of this important insect vector and suggests targets for intervention."

Read more at PNAS' website.

Sam Rund was a biochemistry major and Science Research Fellow at DePauw. He's currently a graduate student at the University of Notre Dame, where he serves as president of the graduate student body.

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